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Transcription Defined

The process by which DNA passes genetic information to RNA. Transcription is the first step in producing proteins.

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Bioengineered foods hold promise "” in the future

Published November 22, 2008, 10:16 pm, Pioneer Press

For years, advocates of agricultural biotechnology have promised a future in which foods will be genetically engineered to provide more nutrition and to prevent chronic diseases, in which crops will be modified to thrive in salty soil or hot or dry climates and in which consumers will benefit directly from science's ability to tweak other characteristics of plants.

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Ideal Time For Stem Cell Collection Defined For Parkinson's Disease Therapy

Published November 22, 2008, 3:28 pm, Science Daily

Researchers have identified a stage during dopamine neuron differentiation that may be an ideal time to collect human embryonic stem cells for transplantation to treat Parkinson's disease, according to new research.

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New insight into the response of human skin to radiation

Published November 21, 2008, 2:02 pm, News-Medical-Net

Scientists have new insight into the response of human skin to radiation and what drives the most aggressive and deadly form of skin cancer.

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Researchers reveal a new aspect of tumor development

Published November 21, 2008, 1:32 pm, News-Medical-Net

The DNA in our cells is constantly under assault from oxygen, the sun's radiation and environmental stresses.

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Scientists Grow New Frog Eyes From Stem Cells

Published November 21, 2008, 7:32 am, AnandTech

Scientist help disabled frogs live fuller lives -- and hopefully someday humans too...

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Tumor Formation May Be Spurred By The Misreading Of Damaged DNA

Published November 21, 2008, 7:08 am, Medical News Today

The DNA in our cells is constantly under assault from oxygen, the sun's radiation and environmental stresses. Most of the time, our cells can repair the damage before it gets copied into a permanent mutation that could lead to cancer.

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Survival Of Melanoma Cells Promoted By Gene Required For Radiation-Induced Protective Pigmentation

Published November 21, 2008, 6:09 am, Medical News Today

Scientists have new insight into the response of human skin to radiation and what drives the most aggressive and deadly form of skin cancer. The research, published by Cell Press in the November 21st issue of the journal Molecular Cell, may be useful in the design of new strategies for prevention of malignant melanoma.

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Lab-on-a-chip advance is promising for researchers

Published November 20, 2008, 8:18 pm, Johns Hopkins News-Letter

Biomedical Engineering's Andre Levchenko and graduate students Raymond Cheong and Joanne Wang have created a new device that is set to change the way cancer is diagnosed and cellular signaling pathways are studied.

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Pluripotent Stem Cells Shown To Generate New Retinal Cells Necessary For Vision, Study Finds

Published November 20, 2008, 7:43 pm, Science Daily

Pluripotent stem cells -- those, like embryonic stem cells, that give rise to almost every type of cell in the body -- can be converted into the different classes of retinal cells necessary for vision, according to a new study.

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Misreading Of Damaged DNA May Spur Tumor Formation

Published November 20, 2008, 3:28 pm, Science Daily

Cells can turn on tumor-promoting growth circuits by falsely reporting critical genetic information during the process of transcription: making RNA from DNA. Damage to the DNA making up a gene can lead to a misreading of the gene as it is made into RNA, a process called transcriptional mutagenesis. Transcriptional mutagenesis could represent an additional way DNA damage contributes to tumor ...

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  • Evolutionary Dynamics of Prokaryotic Transcriptiona l Regulatory Networks: We use the known transcriptiona l regulatory network of Escherichia coli to analyse the conservation patterns of this network across 175 prokaryotic genomes, and predict components of the regulatory networks for these organisms. We observe that transcription factors are typically less conserved than their target genes and evolve independently of them, with different organisms evolving distinct repertoires of transcription factors responding to specific signals.
  • RegulonDB 6.2: E. coli K12 Transcriptiona l Network.
  • DBTBS: a collection of experimentally validated gene regulatory relations and the corresponding transcription factor binding sites upstream of B. subtilis genes. Its current version is constructed by surveying 947 references and contains the information of 120 binding factors and 1475 gene regulatory relations. For each promoter, all of its known cis-elements are listed according to their positions, while these cis-elements are aligned to illustrate the consensus sequence for each transcription factor. All probable transcription factors coded in the genome were classified using Pfam motifs.
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