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Genetics > X-inactivation
The following information is about X-inactivation.
X-inactivation Defined
The repression of one of the two X-chromosomes in the somatic cells of females as a method of dosage compensation; at an early embryonic stage in the normal female, one of the two X-chromosomes undergoes inactivation, apparently at random, from this point on all descendent cells will have the same X-chromosome inactivated as the cell from which they arose, thus a female is a mosaic composed of two types of cells, one which expresses only the paternal X-chromosome, and another which expresses only the maternal X-chromosome.
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Off-site X-inactivation Links, User Submitted
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Fri Sep 19
- Molecular Coupling of Xist Regulation and Pluripotency -- Navarro et al. 321 (5896): 1693 -- Science: "We conclude that the three main genetic factors underlying pluripotency cooperate to repress Xist and thus couple X inactivation reprogramming to the control of pluripotency during embryogenesis. "
Tue Feb 12
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